Comparison of SMR of OpenEpi to other statistical software and textbooks.

| Input | Output
| Observed and expected number of events, and confidence intervals | Mid-P exact two-tailed p | Fisher exact two-tailed p | Exact Confidence limit (Lower, upper)
OpenEpi | 4, 3.3, 95% | 0.6571 | 0.8393 | 0.3303, 3.103
Rosner | NA | 0.839 | NA
Simple Interactive Statistical Analysis (SISA) | 0.65707 | 0.8393 | 0.33026, 3.1035
PEPI | 0.657 | 0.839* | 0.3303, 3.103
OpenEpi | 21, 18.1, 95% | 0.4851 | 0.5546 | 0.7182, 1.773
Rosner | NA | 0.5546 | NA
Simple Interactive Statistical Analysis (SISA) | 0.48507 | 0.5546 | 0.71819, 1.7735
PEPI | 0.481 | 0.551* | 0.7182, 1.7735
OpenEpi | 7678, 11005.654, 95% | <0.00001 | <0.00001 | 0.6821, 0.7134
Simple Interactive Statistical Analysis (SISA) | 0.000 | 0.000 | Not computed because of too many events for a reliable estimate.
PEPI | NA | NA | 0.68212, 0.71342

| Input | Output
| Observed and expected number of events, and confidence intervals | Mid-P Exact two-tailed p | Fisher exact two-tailed p | Byar approximation two-tailed p | Rothman/Greenland Approximation: 95% Confidence limit (Lower, upper)
OpenEpi | 41, 23, 95% | 0.00087 | 0.001141 | 0.00117 | 1.296, 2.39
Rothman & Boice | 0.00087 | 0.001141 | 0.00117 | 1.30, 2.39
Simple Interactive Statistical Analysis (SISA) | 0.00087 | 0.00114 | NA | 1.2957, 2.3898

    References:

    ·        Rosner B. Fundamentals of Biostatistics, 5th Edition. Duxbury  Press, 2000.

· Simple Interactive Statistical Analysis (SISA-Exact module) http://home.clara.net/sisa/smrhlp.htm

· PEPI: Abramson JH and Gahlinger PM (2001). Computer program for epidemiologists: PEPI version 4.0. Sagebrush Press, Salt Lake City.

    ·        Rothman KJ and Greenland S. Modern Epidemiology, 2nd Edition. Lippincott-Raven Publishers, Philadelphia, 1998.

    ·        Rothman KJ and Boice JD  Jr. Epidemiologic analysis with a programmable calculator. NIH Pub No. 79-1649.  Bethesda, MD:  National Institutes of Health, 1979, 31-32.