Documentation for

Confidence Interval of median or percentiles for a given sample size

Minn M. Soe, MD, MPH, MCTM : msoe@sph.emory.edu

Kevin M. Sullivan, PhD, MPH, MHA: cdckms@sph.emory.edu

For non-Normal distribution, the median of the sample or population is preferable to the mean as a measure of location (Rank). Medians are also appropriate in other situations-for example, when measurements are on an ordinal scale.

This module calculates confidence interval around a selected percentile for a sample size given. Entering sample size and desired percentile will calculate 95% confidence interval as a default confidence limit. The user can change the confidence interval by typing in new value. Please note that the selected percentile should be within 1-100%";

The output from the default example is as below:

The interpretation is we are 95% confident that the median position of observation (eg. systolic blood pressure) in the sample may be between 40th – 61th position among observations arranged in increasing order. This confidence interval is calculated by normal approximation method of large sample size theory. Then, read the corresponding values of observation (eg. systolic blood pressure) at 40th and 61th position in the sample dataset. They will be 95% confidence interval of median systolic blood pressure of the sample. Currently, all confidence intervals calculated are two-sided confidence intervals, and lower limit and upper limit are rounded to nearest integer. The formulae for the method are provided below.

Formulae

The notation for the formulae are:

N1-α/2 = z-statistics from the standard Normal distribution for the 100(1- α/2) percentile.

n = sample size

References:

"Normal approximation" method based on Martin J Gardner, Douglas G Altman, Statistics with confidence, Chapter 8, pp 71-73.

Acknowledgement:

Default values are derived from the same chapter: sample size=100, median (50th percentile) and 95% confidence interval.